Wei J, Hemmings G P
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bangor, Gwyndedd, UK.
Psychiatr Genet. 1999 Dec;9(4):183-6. doi: 10.1097/00041444-199912000-00003.
Family-based studies have been conducted with restriction fragment length polymorphism (RFLP) analysis for testing association between polymorphisms for the catechol-O-methyltransferase (COMT) locus and schizophrenia in 49 Caucasian nuclear families consisting of fathers, mothers and offspring affected with schizophrenia. The present results did not support the hypothesis that the COMT gene might play an important role in predisposing an individual to a genetic risk for schizophrenia. Neither did we find a significant association of the COMT locus with violent behaviour in schizophrenia. Nevertheless, there may be a susceptibility gene for schizophrenia in a distinct region from the COMT locus on chromosome 22q, as a genome scan has suggested recently.
针对49个由患有精神分裂症的父亲、母亲和后代组成的白种人核心家庭，开展了基于家系的研究，采用限制性片段长度多态性（RFLP）分析来检测儿茶酚-O-甲基转移酶（COMT）基因座多态性与精神分裂症之间的关联。目前的结果并不支持COMT基因可能在使个体易患精神分裂症遗传风险方面发挥重要作用这一假设。我们也未发现COMT基因座与精神分裂症中的暴力行为存在显著关联。然而，正如最近一项基因组扫描所提示的，在22号染色体上与COMT基因座不同的一个区域可能存在精神分裂症的易感基因。
