中缝大核在吗啡镇痛中的作用：大鼠脑内微量注射研究
[Role of the Raphe Magnus nucleus in morphine analgesia : studies with intracerebral microinjections in the rat].
作者信息
Dickenson A H, Oliveras J L, Besson J M
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Oct 23;287(10):955-8.
PMID:106979
Abstract
Microinjections of low concentration of morphine (5 micrograms) into the nucleus Raphé Magnus of the Rat produce a strong analgesia that can be reversed by systemic naloxone, an opiate antagonist. The administration of naloxone (5 micrograms) into the Raphé Magnus considerably reduces the effects of intravenous morphine. The effects of microinjections of morphine are strongly reduced by Cinanserin, suggesting a role for serotoninergic mechanisms in morphine analgesia.
摘要
向大鼠中缝大核微量注射低浓度吗啡（5微克）会产生强烈的镇痛作用，该作用可被阿片拮抗剂纳洛酮全身给药逆转。向中缝大核注射纳洛酮（5微克）可显著降低静脉注射吗啡的效果。西咪替丁可显著降低微量注射吗啡的效果，提示5-羟色胺能机制在吗啡镇痛中起作用。
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