Waters A P, Janse C J
Department of Parasitology, Leiden University Medical Centre, The Netherlands.
Parassitologia. 1999 Sep;41(1-3):453-9.
The genetic manipulation of malaria parasites is a rapidly emerging technology that offers great promise for the investigation of many aspects of infection. Currently it is possible to transform avian, rodent, primate as well as human parasites, the latter three on a stable, drug selectable basis. This review focuses on the history of the development of the technology, current abilities and future perspectives.
疟原虫的基因操作是一项迅速兴起的技术，在感染的诸多方面研究中具有巨大潜力。目前，已能够对禽类、啮齿类、灵长类以及人类疟原虫进行转化，后三种疟原虫可在稳定的药物选择基础上进行转化。本文综述聚焦于该技术的发展历程、当前能力及未来前景。
