Chang S N, Chun S I, Moon T K, Park W H
Department of Dermatology, College of Medicine, Pochon CHA University, Pundang CHA Hospital, Kyonggi-do, Korea.
Am J Dermatopathol. 2000 Feb;22(1):22-5. doi: 10.1097/00000372-200002000-00004.
Two cases showing changes of sclerotic fibroma developed in association with an inflammatory process, especially folliculitis. The lesion in the first case showed a well-circumscribed, nonencapsulated nodule in the dermis, which consisted of a perifollicular fibrotic area and a peripheral sclerotic area. In addition to the usual findings of sclerotic fibroma, spindle cells were heavily infiltrated in a storiform and fascicular pattern around the degenerated hair follicle, suggestive of dermatofibroma. The lesion in the second case showed the typical findings of sclerotic fibroma in association with folliculitis and hair follicle remnants. Our observations suggest that solitary sclerotic fibroma of the skin may be a degenerated or sclerotic end stage of other fibrous conditions, such as dermatofibroma, and that it may be induced by inflammation, especially folliculitis.
两例显示硬化性纤维瘤改变的病例与炎症过程相关，尤其是毛囊炎。第一例病变表现为真皮内边界清楚、无包膜的结节，由毛囊周围纤维化区域和外周硬化区域组成。除了硬化性纤维瘤的常见表现外，梭形细胞以车辐状和成束状模式大量浸润于退化毛囊周围，提示皮肤纤维瘤。第二例病变表现为硬化性纤维瘤合并毛囊炎及毛囊残余的典型表现。我们的观察结果提示，皮肤孤立性硬化性纤维瘤可能是其他纤维性疾病（如皮肤纤维瘤）的退化或硬化终末期，且可能由炎症尤其是毛囊炎诱发。
