Pujol R M, de Castro F, Schroeter A L, Su W P
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Am J Dermatopathol. 1996 Dec;18(6):620-4. doi: 10.1097/00000372-199612000-00013.
Two cases of solitary tumors showing well-demarcated hypocellular, dermal fibrocollagenous proliferations are reported. The lesions were composed of hyalinized eosinophilic collagen bundles arranged in the characteristic interwoven pattern with prominent clefts, as described in sclerotic fibroma of the skin. This pattern, although predominant, was not uniform. Some areas showed a more cellular pattern with histopathologic features suggestive of dermatofibroma. In those areas, multiple spindle-shaped cells and occasional multinucleated cells were observed. The collagen bundles did not adopt a whorled pattern, and the overlying epidermis showed mild acanthosis and elongation of the rete ridges. The sclerotic changes were present mainly at the periphery and in the deep areas of the tumor. Our observations confirm the possibility that solitary sclerotic fibroma of the skin may represent, at least in some instances, the later and sclerotic stage of other more cellular neoplasms (specifically dermatofibromas) rather than an individualized neoplasm, as has been recently proposed.
报告了两例孤立性肿瘤，其表现为边界清晰的细胞减少性真皮纤维胶原增生。病变由透明化的嗜酸性胶原束组成，呈特征性的交织模式，伴有明显的裂隙，如皮肤硬化性纤维瘤中所描述的那样。这种模式虽然占主导，但并不一致。一些区域显示出细胞较多的模式，其组织病理学特征提示为皮肤纤维瘤。在这些区域，观察到多个梭形细胞和偶尔的多核细胞。胶原束未呈漩涡状模式，上方表皮显示轻度棘层增厚和 rete 嵴延长。硬化改变主要存在于肿瘤的周边和深部区域。我们的观察结果证实了这样一种可能性，即皮肤孤立性硬化性纤维瘤至少在某些情况下可能代表其他细胞较多的肿瘤（特别是皮肤纤维瘤）的后期硬化阶段，而不是一种独立的肿瘤，正如最近所提出的那样。
