Cohen J H, Atkinson J P, Klickstein L B, Oudin S, Subramanian V B, Moulds J M
Laboratoire d'Immunologie, Pôle Biomolécules, IFR 53, Université de Reims Champagne Ardennes, URCA, France.
Mol Immunol. 1999 Sep-Oct;36(13-14):819-25. doi: 10.1016/s0161-5890(99)00102-9.
This report is devoted to methodologies used in analyzing the C3b/C4b receptor (CR1, CD35) on erythrocytes (E), its soluble form, the CRI structural or allotype polymorphism, and CR1 density polymorphism. In primates E CR1 serves as the main system for processing and clearance of complement opsonized immune complexes (IC). CR1 copy numbers decrease with aging of E in normal individuals. Erythrocyte CR1 is also decreased in pathological conditions such as systemic lupus erythematosus (SLE), HIV infection, certain hemolytic anemias, and many other conditions featuring immune complexes. Consequently, CRI on E has an important physiological role in immune complex handling and has interesting alterations in disease.
本报告致力于分析红细胞（E）上C3b/C4b受体（CR1，CD35）、其可溶性形式、CR1结构或同种异型多态性以及CR1密度多态性所使用的方法。在灵长类动物中，E CR1是处理和清除补体调理的免疫复合物（IC）的主要系统。在正常个体中，CR1拷贝数随E的衰老而减少。在系统性红斑狼疮（SLE）、HIV感染、某些溶血性贫血以及许多其他以免疫复合物为特征的病理状况下，红细胞CR1也会减少。因此，E上的CRI在免疫复合物处理中具有重要的生理作用，并且在疾病中会发生有趣的改变。
