Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.
作者信息
Hayashi Y, Iijima K, Katada J, Kiso Y
机构信息
Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
出版信息
Bioorg Med Chem Lett. 2000 Feb 7;10(3):199-201. doi: 10.1016/s0960-894x(99)00659-9.
Abstract
Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.
摘要
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