Wang C R, Liu S T, Liu M F, Lee G L, Wang G R, Chuang C Y
Department of Internal Medicine, National Cheng-Kung University Hospital, Taiwan, ROC.
Asian Pac J Allergy Immunol. 1999 Dec;17(4):249-54.
The IFN-gamma produced by Th1 cells and IL-4 produced by Th2 cells are two most important cytokines in the regulation of IgE production. House dust immunotherapy has been tried in the treatment of house dust-sensitive Chinese asthmatic patients with good results. We examined the influence of such treatment on in vitro IL-4 and IFN-gamma production by peripheral blood mononuclear cells in house dust-sensitive asthmatic patients. Allergen immunotherapy in house-dust sensitive asthmatic patients can significantly decrease IL-4 production from peripheral mononuclear cells (p<0.05). The production levels of IL-4 in patients without treatment had higher levels than those in patients with hyposensitization (p<0.01). Such therapy also have some effect on promotion of IFN-gamma production in asthmatic patients. In conclusion, immunotherapy with house dust may have the potential ability to shift the Th1/Th2 balance of immune response to allergens and to create a favorable cytokine microenvironment to suppress the allergic reaction in the asthmatic airway.
Th1细胞产生的干扰素-γ和Th2细胞产生的白细胞介素-4是调节IgE产生的两种最重要的细胞因子。尘螨免疫疗法已用于治疗对尘螨敏感的中国哮喘患者，效果良好。我们研究了这种治疗对尘螨敏感哮喘患者外周血单个核细胞体外产生白细胞介素-4和干扰素-γ的影响。对尘螨敏感的哮喘患者进行变应原免疫疗法可显著降低外周单个核细胞产生白细胞介素-4的水平（p<0.05）。未治疗患者的白细胞介素-4产生水平高于减敏治疗患者（p<0.01）。这种疗法对促进哮喘患者产生干扰素-γ也有一定作用。总之，尘螨免疫疗法可能具有改变针对变应原的免疫反应中Th1/Th2平衡的潜在能力，并创造有利的细胞因子微环境以抑制哮喘气道中的过敏反应。
