Zheng T, Holford T R, Mayne S T, Tessari J, Ward B, Carter D, Owens P H, Boyle P, Dubrow R, Archibeque-Engle S, Dawood O, Zahm S H
Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut 06520, USA.
Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):167-74.
This case-control study was designed to investigate the relationship between polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2'-bis(p-chlorophenyl)ethylene (DDE) and breast cancer risk in Connecticut. Cases were incident breast cancer patients who were either residents of Tolland County or who had a breast-related surgery at the Yale-New Haven Hospital in New Haven County. Controls were randomly selected from Tolland County residents or from patients who had newly diagnosed benign breast diseases or normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502 controls had their serum samples analyzed for PCBs and DDE in 1995-1997. The age- and lipid-adjusted geometric mean serum level of DDE was comparable between the cases (460.1 ppb) and controls (456.2 ppb). The geometric mean serum level of PCBs was also comparable between cases (733.1 ppb) and controls (747.6 ppb). After adjustment for confounding factors, odds ratios of 0.96 (95% confidence interval, 0.67-1.36) for DDE and 0.95 (95% confidence interval, 0.68-1.32) for PCBs were observed when the third tertile was compared with the lowest. Further stratification by parity, lactation, and menopausal and estrogen receptor status also showed no significant association with serum levels of DDE or PCBs. The results by PCB congener groups also showed no major increased risk associated with any of the congener groups. Our study does not support the hypothesis that DDE and PCBs, as encountered through environmental exposure, increase the risk of female breast cancer.
这项病例对照研究旨在调查多氯联苯（PCBs）和1,1-二氯-2,2'-双（对氯苯基）乙烯（DDE）与康涅狄格州乳腺癌风险之间的关系。病例为新确诊的乳腺癌患者，他们要么是托兰县居民，要么在纽黑文县的耶鲁-纽黑文医院接受过与乳房相关的手术。对照是从托兰县居民中随机选取的，或者是从耶鲁-纽黑文医院新诊断为良性乳腺疾病或正常组织的患者中选取的。1995年至1997年期间，共有475例病例和502例对照的血清样本接受了PCBs和DDE分析。病例组（460.1 ppb）和对照组（456.2 ppb）的年龄和脂质调整后的DDE几何平均血清水平相当。病例组（733.1 ppb）和对照组（747.6 ppb）的PCBs几何平均血清水平也相当。在对混杂因素进行调整后，将第三分位数与最低分位数相比，DDE的优势比为0.96（95%置信区间，0.67 - 1.36），PCBs的优势比为0.95（95%置信区间，0.68 - 1.32）。按产次、哺乳情况、绝经状态和雌激素受体状态进一步分层，也未显示与DDE或PCBs血清水平有显著关联。按PCB同系物组分析的结果也未显示与任何同系物组有重大的风险增加。我们的研究不支持环境暴露所接触到的DDE和PCBs会增加女性乳腺癌风险这一假设。
