Brown A S, Cohen P, Greenwald S, Susser E
New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Am J Psychiatry. 2000 Mar;157(3):438-43. doi: 10.1176/appi.ajp.157.3.438.
The authors' goal was to investigate the suggestion of previous investigations that prenatal viral exposures might increase the later risk of psychotic disorders.
They conducted a follow-up study in young adulthood of a birth cohort that was previously documented, by clinical examination and serological testing, to have in utero rubella exposure during the 1964 rubella epidemic. Data were also obtained from an unexposed birth cohort and from the Epidemiological Catchment Area survey. Young adult subjects were administered a standard psychiatric diagnostic interview. The authors compared the proportions of subjects with nonaffective psychosis in the exposed and unexposed cohorts.
The rubella-exposed subjects, most of whom were exposed in the first trimester, demonstrated a substantially greater risk for nonaffective psychosis than the subjects who were not exposed to rubella (relative risk=5.2).
There is an association between clinically and serologically diagnosed prenatal viral infection and nonaffective psychosis in adulthood.
作者的目标是调查先前研究提出的产前病毒暴露可能增加后期患精神障碍风险的这一观点。
他们对一个出生队列进行了青年期随访研究，该队列先前经临床检查和血清学检测记录，在1964年风疹流行期间子宫内有风疹暴露情况。数据还来自一个未暴露的出生队列和流行病学集水区调查。对青年期受试者进行了标准的精神科诊断访谈。作者比较了暴露队列和未暴露队列中患有非情感性精神病的受试者比例。
风疹暴露受试者中大多数在孕早期暴露，与未暴露于风疹的受试者相比，其患非情感性精神病的风险显著更高（相对风险=5.2）。
临床和血清学诊断的产前病毒感染与成年期非情感性精神病之间存在关联。
