注意缺陷多动障碍与早发型和晚发型双相情感障碍的共病情况。
Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder.
作者信息
Sachs G S, Baldassano C F, Truman C J, Guille C
机构信息
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Am J Psychiatry. 2000 Mar;157(3):466-8. doi: 10.1176/appi.ajp.157.3.466.
OBJECTIVE
The relationship between attention deficit hyperactivity disorder (ADHD) and earlier age at onset of affective illness was examined in probands with a history of bipolar disorder.
METHOD
The authors assessed 56 adult bipolar subjects. Those with a history of childhood ADHD (N=8) were age and sex matched with bipolar subjects without a history of childhood ADHD (N=8).
RESULTS
The age at onset of the first affective episode was lower for the subjects with bipolar disorder and a history of childhood ADHD (mean=12.1 years, SD=4.6) than for those without a history of childhood ADHD (mean=20. 0 years, SD=11.3).
CONCLUSIONS
ADHD in children of bipolar probands might identify children at highest risk for development of bipolar disorder.
目的
在有双相情感障碍病史的先证者中，研究注意缺陷多动障碍（ADHD）与情感性疾病发病年龄较早之间的关系。
方法
作者评估了56名成年双相情感障碍患者。有儿童期ADHD病史的患者（N = 8）在年龄和性别上与无儿童期ADHD病史的双相情感障碍患者（N = 8）相匹配。
结果
有双相情感障碍且有儿童期ADHD病史的患者首次情感发作的年龄（平均 = 12.1岁，标准差 = 4.6）低于无儿童期ADHD病史的患者（平均 = 20.0岁，标准差 = 11.3）。
结论
双相情感障碍先证者子女中的ADHD可能可识别出双相情感障碍发病风险最高的儿童。
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