Wade T D, Bulik C M, Neale M, Kendler K S
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond 23298-0126, USA.
Am J Psychiatry. 2000 Mar;157(3):469-71. doi: 10.1176/appi.ajp.157.3.469.
The authors sought to derive heritability estimates for anorexia nervosa and to explore the etiology of the comorbid relationship between anorexia nervosa and major depression.
They applied bivariate structural equation modeling to a broad definition of anorexia nervosa and lifetime major depression as assessed in a population-based sample of 2,163 female twins.
Anorexia nervosa was estimated to have a heritability of 58% (95% confidence interval=33%-84%). The authors were unable to completely rule out a contribution of shared environment. The comorbidity between anorexia nervosa and major depression is likely due to genetic factors that influence the risk for both disorders.
Although the study was limited by the small number of affected twins, the results suggest that genetic factors significantly influence the risk for anorexia nervosa and substantially contribute to the observed comorbidity between anorexia nervosa and major depression.
作者试图得出神经性厌食症的遗传度估计值，并探讨神经性厌食症与重度抑郁症共病关系的病因。
他们将双变量结构方程模型应用于对神经性厌食症和终生重度抑郁症的广义定义，这些数据来自于对2163名女性双胞胎进行的基于人群的样本评估。
神经性厌食症的遗传度估计为58%（95%置信区间=33%-84%）。作者无法完全排除共享环境的影响。神经性厌食症与重度抑郁症的共病可能是由于影响这两种疾病风险的遗传因素。
尽管该研究受到受影响双胞胎数量较少的限制，但结果表明遗传因素显著影响神经性厌食症的风险，并在很大程度上导致了观察到的神经性厌食症与重度抑郁症的共病现象。
