Nilsson A, Broomé-Karlsson A
Acta Radiol Ther Phys Biol. 1976 Oct;15(5):417-26. doi: 10.3109/02841867609131776.
Groups of female CBA-mice were given 90Sr (14.8 kBq/g-0.4muCi/g--bodyweight) alone or in combination with polyestrodiolphosphate, methylprednisolone or nortestosterone, respectively. When 90Sr was given in the first combination, the frequency of osteosarcomas was significantly increased whereas the tumour latency time was decreased compared to mice given 90Sr alone. In combination with nortestosterone such effects were not found, whereas the combination 90Sr + methylprednisolone resulted in a strong reduction of the osteosarcoma incidence and a prolonged tumour latency time. The latter experiment was repeated in a larger experiment whereby the results were confirmed.
将雌性CBA小鼠分组，分别单独给予90锶（14.8千贝可/克 - 0.4微居里/克 - 体重），或与多聚雌二醇磷酸酯、甲基强的松龙或诺睾酮联合给予。当以第一种组合给予90锶时，与单独给予90锶的小鼠相比，骨肉瘤的发生率显著增加，而肿瘤潜伏期缩短。与诺睾酮联合使用时未发现此类效应，而90锶 + 甲基强的松龙的组合导致骨肉瘤发生率大幅降低且肿瘤潜伏期延长。后一项实验在更大规模的实验中重复进行，结果得到证实。
