Gebuhr T C, Bultman S J, Magnuson T
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Genesis. 2000 Mar;26(3):189-97. doi: 10.1002/(sici)1526-968x(200003)26:3<189::aid-gene4>3.0.co;2-5.
Pc-G and trx-G genes are responsible for maintenance of transcriptional regulation and provide a cellular memory mechanism throughout development. Studies in fly, yeast, mouse, and human have implicated modulation of higher-order chromatin structure as an important component in this process. Specifically, connections between SWI/SNF complexes and trx-G genes have provided a mechanistic link between chromatin remodeling and transcriptional regulation. Here we discuss recent genetic and biochemical data that has shed light on the molecular mechanisms and pathways associated with Pc-G and trx-G function in developmental processes such as cell cycle control and hematopoiesis. genesis 26:189-197, 2000.
多梳基因家族（Pc-G）和三胸节基因家族（trx-G）负责维持转录调控，并在整个发育过程中提供一种细胞记忆机制。对果蝇、酵母、小鼠和人类的研究表明，高阶染色质结构的调节是这一过程的重要组成部分。具体而言，SWI/SNF复合物与trx-G基因之间的联系为染色质重塑和转录调控提供了一种机制性联系。在此，我们讨论了最近的遗传和生化数据，这些数据揭示了在细胞周期控制和造血等发育过程中，与Pc-G和trx-G功能相关的分子机制和途径。《基因》2000年第26卷：第189 - 197页。
