Ostrowski R P
Department of Neuropathology, Medical Research Centre, PASci, Warszawa.
Folia Neuropathol. 1999;37(4):247-51.
The aim of the work was to evaluate the influence of CoQ10 on superoxide dismutase (SOD) activity levels in the rat model of cerebral ischemia induced by endothelins (ET-1 or ET-3). ETs (20 pmol) were injected into the right lateral cerebral ventricle and immediately CoQ10 was given intraperitoneally (10 mg/kg b.w.). In the brains of experimental animals subjected both to ET-1 and ET-2 administration there was observed a decrease of SOD activity in the brain stem, in the cerebrallum and in the cerebral cortex at all time intervals. ET-1, as compared to ET-3 evoked longer lasting disturbances in SOD activity. In the cerebellum and in the cerebral cortex positive effect of CoQ10 and recovery to the control values was noted after 4 hours in the group subjected to ET-3 injection and after 24 hours in the ET-1 treated animal. Investigated brain areas showed different sensitivity to ETs. Above data may indicate on beneficial effect CoQ10 in the cerebral ischemia via decrease of free radicals concentration.
这项工作的目的是评估辅酶Q10对由内皮素（ET-1或ET-3）诱导的大鼠脑缺血模型中超氧化物歧化酶（SOD）活性水平的影响。将内皮素（20皮摩尔）注入右侧侧脑室，随后立即腹腔注射辅酶Q10（10毫克/千克体重）。在同时接受ET-1和ET-2给药的实验动物大脑中，在所有时间间隔内，脑干、大脑和大脑皮层中的SOD活性均出现下降。与ET-3相比，ET-1引起的SOD活性干扰持续时间更长。在接受ET-3注射的组中，4小时后在小脑和大脑皮层中观察到辅酶Q10的积极作用并恢复到对照值，而在接受ET-1治疗的动物中，24小时后恢复到对照值。所研究的脑区对内皮素表现出不同的敏感性。上述数据可能表明辅酶Q10通过降低自由基浓度对脑缺血具有有益作用。
