Iwatani M, Wasada T, Iwamoto Y, Kamatani N
Institute of Rheumatology, Tokyo Women's Medical University.
Nihon Rinsho. 2000 Feb;58(2):430-4.
Gout patients often have various characteristics of insulin resistance (IR) syndrome such as glucose intolerance, hyperlipidemia, hypertension and obesity. In addition, epidemiological data suggest that hyperuricemia is associated with higher rates of death due to cardiovascular and cerebrovascular disorders. However, it has not conclusively been shown whether the association between hyperuricemia and increased death rate is secondary to the association between IR and death or hyperuricemia itself is an independent risk of death. It is of interest to examine the effects of insulin sensitizer which was developed recently on serum urate concentration because it may provide a new idea as to the mechanism of the association between IR, hyperuricemia and vascular disorders. In the present paper, we discuss the relevance of IR to hyperuricemia and gout, and show the data of urate and glucose metabolism obtained from control subjects or the patients with hyperuricemia, gout or type 2 diabetes.
痛风患者常具有胰岛素抵抗（IR）综合征的各种特征，如糖耐量异常、高脂血症、高血压和肥胖。此外，流行病学数据表明，高尿酸血症与心血管和脑血管疾病导致的较高死亡率相关。然而，高尿酸血症与死亡率增加之间的关联是继发于IR与死亡之间的关联，还是高尿酸血症本身就是死亡的独立风险，尚未得到确凿证实。研究最近开发的胰岛素增敏剂对血清尿酸盐浓度的影响很有意义，因为这可能为IR、高尿酸血症和血管疾病之间关联的机制提供新思路。在本文中，我们讨论了IR与高尿酸血症和痛风的相关性，并展示了从对照组或高尿酸血症、痛风或2型糖尿病患者获得的尿酸和葡萄糖代谢数据。
