Carrive P
School of Anatomy, University of New South Wales, Sydney, NSW, Australia.
Brain Res. 2000 Mar 10;858(2):440-5. doi: 10.1016/s0006-8993(00)02029-1.
This study compares the time course of the cardiovascular changes (mean arterial blood pressure, heart rate) and behavioral changes (freezing, rearing, grooming and activity) evoked by 30 min long exposures to a footshock chamber before and after conditioning with footshocks. The main finding is that the conditioned fear evoked by re-exposure to the footshock chamber after conditioning is associated with a prolonged freezing response, a marked rise in mean arterial pressure (+35 mm Hg above a resting baseline of 105 mm Hg) and a delayed rise in heart rate. The pattern of behavioral and cardiovascular changes is the same as with conditioned fear to a discrete stimulus but the effect is a lot longer.
本研究比较了在足部电击条件反射前后，暴露于足部电击箱30分钟所引发的心血管变化（平均动脉血压、心率）和行为变化（僵住、竖毛、理毛和活动）的时间进程。主要发现是，在条件反射后再次暴露于足部电击箱所引发的条件性恐惧与延长的僵住反应、平均动脉血压显著升高（比105毫米汞柱的静息基线高出35毫米汞柱）以及心率延迟升高有关。行为和心血管变化的模式与对离散刺激的条件性恐惧相同，但影响持续时间长得多。
