Sevastikoglou J A, Mattsson S
Acta Chir Scand Suppl. 1976;467:31-5.
Inactivity of the right hind leg was brought about in adult male Sprague-Dawley rats by a) immobilisation in a plaster cast and b) by resection of the sciatic nerve. Determinations of the volume and the activity of the parathyroid glands by morphological methods showed that the parathyroids were, on the whole, not affected by the treatment. Some significant differences observed in some examined parameters should, however, suggest hypofunction of the glands. The serum-calcium level was significantly higher in the treated than in the control rats in the first experiment. No significant differences in serum calcium between treated and control animals were observed in the second experiment. These observations were considered to indicate that the development of localised osteoporosis in these two forms of inactivity did not depend on hyperactivity of the parathyroids. The observed differences in serum-calcium content between the two experiments may suggest that localised osteoporosis in the two cases developed through different pathomechanisms.
通过以下两种方法致使成年雄性斯普拉格-道利大鼠右后肢失活：a) 用石膏固定；b) 切除坐骨神经。通过形态学方法测定甲状旁腺的体积和活性，结果表明总体而言，甲状旁腺未受该治疗影响。然而，在一些检测参数中观察到的一些显著差异表明腺体功能减退。在第一个实验中，治疗组大鼠的血清钙水平显著高于对照组。在第二个实验中，未观察到治疗组和对照组动物血清钙有显著差异。这些观察结果被认为表明这两种失活形式导致的局部骨质疏松症的发展并不依赖于甲状旁腺功能亢进。两个实验中观察到的血清钙含量差异可能表明这两种情况下的局部骨质疏松症是通过不同的病理机制发展而来的。
