Lindskog S, Zetterström O, Kamkar A, Bergman E, Forsgårdh A, Blomlöf L
Department of Basic Oral Sciences, School of Dentistry, Karolinska Institute, Stockholm, Sweden.
Int J Periodontics Restorative Dent. 1999 Aug;19(4):373-7.
The present study tested the hypothesis that treatment-resistant periodontitis patients present with a more intense inflammatory response to marginal bacterial plaque as a sign of an inflammatory overreaction. Patients with severe marginal periodontitis (Gingival Index > 20%) who had not responded to treatment showed almost no positive response to lipid A in a skin-prick test, which was significantly different from the results from patients with severe marginal periodontitis who had responded to treatment and from healthy control individuals without marginal periodontitis. This finding can be interpreted as an impaired inflammatory reactivity to periodontitis pathogens in treatment-resistant patients, rejecting the hypothesis.
治疗抵抗性牙周炎患者对边缘细菌菌斑呈现更强烈的炎症反应，这是炎症过度反应的一个迹象。对治疗无反应的重度边缘性牙周炎患者（牙龈指数>20%）在皮肤点刺试验中对脂多糖几乎没有阳性反应，这与对治疗有反应的重度边缘性牙周炎患者以及无边缘性牙周炎的健康对照个体的结果有显著差异。这一发现可解释为治疗抵抗性患者对牙周炎病原体的炎症反应性受损，从而否定了该假设。
