Knox K W
Aust Dent J. 1976 Oct;21(5):397-404. doi: 10.1111/j.1834-7819.1976.tb05095.x.
The inflammatory changes typical of periodontal disease are believed to involve immunological reactions, with bacteria being a potential source of the antigens inducing these reactions, with bacteria being a potential source of the antigens inducing these reactions. Various investigators have studied the ability of specific organisms to induce tissue changes in experimental animals, while others have examined human sera and tissues for the presence of antibodies reacting with particular organisms or their isolated antigens. The significance of these results is assessed, particularly with respect to the problem of antibody cross-reactivity. The antigens that could be involved in periodontal disease are discussed in terms of the difference in structure of Gram-positive and Gram-negative bacterial cells, with attention being drawn to those components that could occur extracellularly and thus diffuse into oral tissues. The antigen most studied is the lipopolysaccharide or endotoxin of Gram-negative cells which, through the mediation of complement, is a potential inflammatory agent.
牙周病典型的炎症变化被认为涉及免疫反应，细菌是诱导这些反应的抗原的潜在来源。许多研究者研究了特定生物体在实验动物中诱导组织变化的能力，而其他研究者则检测了人血清和组织中是否存在与特定生物体或其分离抗原发生反应的抗体。对这些结果的意义进行了评估，特别是关于抗体交叉反应性的问题。根据革兰氏阳性菌和革兰氏阴性菌细胞结构的差异，讨论了可能与牙周病有关的抗原，并关注那些可能存在于细胞外从而扩散到口腔组织中的成分。研究最多的抗原是革兰氏阴性菌细胞的脂多糖或内毒素，它通过补体的介导，是一种潜在的炎症介质。
