小鼠甲状腺刺激素不会刺激人类甲状腺的证据。

Evidence that mouse thyroid stimulator does not stimulate the human thyroid gland.

作者信息

Adams D D, Kennedy T H, Stewart R D

出版信息

Aust N Z J Med. 1976 Aug;6(4):300-4. doi: 10.1111/imj.1976.6.4.300.

DOI:10.1111/imj.1976.6.4.300

Abstract

Thyroid 131I uptake and human thyroid stimulator (HTS) level were measured in 20 untreated thyrotoxic patients who also showed mouse thyroid stimulator (MTS) ACtivity. The correlation between thyroid uptake and HTS level was highly significant (P less than 0-005), the coefficient, r, being 0-66, comparable with the value 0-68 obtained in a previous study of patients not showing MTS. Thus, the presence of widely varying amounts of MTS does not impair the close correlation existing between HTS level and thyroid 131I uptake in thyrotoxic people. There was no correlation between MTS level and thyroid 131I uptake (r = 0-11, n.s.). It is concluded that MTS, a potent stimulator of the thyroid glands of mice, guinea pigs and monkeys, does not stimulate the human thyroid gland.

摘要

对20例未经治疗的甲状腺毒症患者进行了甲状腺131碘摄取及人甲状腺刺激素（HTS）水平的测定，这些患者同时还表现出小鼠甲状腺刺激素（MTS）活性。甲状腺摄取与HTS水平之间的相关性非常显著（P小于0.005），相关系数r为0.66，与之前对未表现出MTS的患者研究中获得的0.68值相当。因此，大量不同水平MTS的存在并不损害甲状腺毒症患者中HTS水平与甲状腺131碘摄取之间存在的密切相关性。MTS水平与甲状腺131碘摄取之间无相关性（r = 0.11，无统计学意义）。得出的结论是，MTS作为小鼠、豚鼠和猴甲状腺的一种强效刺激物，并不刺激人甲状腺。