Mittra R A, Pollack J S, Dev S, Han D P, Mieler W F, Pulido J S, Connor T B
Vitreoretinal Section of the Eye Institute, Medical College of Wisconsin, Milwaukee, USA.
Ophthalmology. 2000 Mar;107(3):588-92. doi: 10.1016/s0161-6420(99)00083-4.
To determine whether topical aqueous suppressant therapy applied after pars plana vitrectomy with gas tamponade prevents postoperative intraocular pressure (IOP) elevation.
Prospective, nonrandomized comparative study.
Forty-one patients who met inclusion criteria and underwent pars plana vitrectomy with gas tamponade (SF6 18%-20% or C3F8 12%-16%) over a 1-year period.
Treatment eyes received topical aqueous suppressants at the end of surgery.
Postoperative IOP at 4 to 6 hours, 1 day, and 1 week.
Twenty-one control and 20 treatment eyes met the inclusion criteria. The IOP (in mmHg) measured at 4 to 6 hours (23.05 [control, 14.73 [treatment]) and 1 day (23.24 [control], 17.28 [treatment]) postoperatively showed a statistically significant difference between the groups (P = 0.0038) at 4 to 6 hours and a trend toward significance (P = 0.057) at 1 day. Eleven control and three treatment eyes had an IOP spike above 25 mmHg at 4 to 6 hours or 1 day postoperatively (P = 0.02), and six control eyes and one treatment eye had postoperative IOP greater than 30 mmHg. A pressure rise greater than 40 mmHg was seen in two control eyes and no treatment eyes.
Use of topical aqueous suppressants after pars plana vitrectomy with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in most cases.
确定在玻璃体切除联合气体填塞术后应用局部水性抑制剂疗法是否可预防术后眼压（IOP）升高。
前瞻性、非随机对照研究。
41例符合纳入标准且在1年期间内接受玻璃体切除联合气体填塞（六氟化硫18%-20%或八氟丙烷12%-16%）的患者。
治疗组在手术结束时接受局部水性抑制剂治疗。
术后4至6小时、1天和1周时的眼压。
21只对照眼和20只治疗眼符合纳入标准。术后4至6小时（对照组23.05，治疗组14.73）和1天（对照组23.24，治疗组17.28）测量的眼压在两组之间4至6小时时有统计学显著差异（P = 0.0038），1天时具有显著趋势（P = 0.057）。11只对照眼和3只治疗眼在术后4至6小时或1天时眼压峰值高于25 mmHg（P = 0.02），6只对照眼和1只治疗眼术后眼压大于30 mmHg。两只对照眼出现了大于40 mmHg的眼压升高，治疗组未出现。
在玻璃体切除联合长效气体填塞术后使用局部水性抑制剂疗法在大多数情况下可有效预防术后显著的眼压升高。
