B-1细胞：正统还是墨守成规？

B-1 cells: orthodox or conformist?

作者信息

Su I, Tarakhovsky A

机构信息

Laboratory of Lymphocyte Signaling, Institute for Genetics, University of Köln, Köln, D-50931, Germany.

出版信息

Curr Opin Immunol. 2000 Apr;12(2):191-4. doi: 10.1016/s0952-7915(99)00071-0.

DOI:10.1016/s0952-7915(99)00071-0

PMID:10712945

Abstract

B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 cell development attributes the properties of B-1 cells to their unique origin. The induced differentiation hypothesis suggests the surface-immunoglobulin-driven development of B-1 cells from common B-1/B-2 cell progenitors. In both models self-antigen-induced signalling plays the central role in positive selection of B-1 cells. The ability of B-1 cells to be positively selected by self-antigens raises questions about the mechanism of this phenomenon.

摘要

B-1细胞在解剖位置、表面标志物表达、抗体库和生长特性等方面与传统外周B细胞（B-2细胞）不同。B-1细胞发育的谱系假说将B-1细胞的特性归因于其独特的起源。诱导分化假说认为B-1细胞是由常见的B-1/B-2细胞祖细胞经表面免疫球蛋白驱动发育而来。在这两种模型中，自身抗原诱导的信号传导在B-1细胞的阳性选择中起核心作用。B-1细胞被自身抗原阳性选择的能力引发了关于这一现象机制的问题。