Vantelon J M, Koscielny S, Brault P, Bourhis J H, Ribrag V, Pico J, Fenaux P, Munck J N
Department of Medicine, Institut Gustave Roussy, Villejuif, France.
Bone Marrow Transplant. 2000 Mar;25(5):495-9. doi: 10.1038/sj.bmt.1702201.
Fifty-six patients with chemosensitive NHL were studied to assess factors affecting mobilization and peripheral blood stem cell (PBSC) collection: all were mobilized with high-dose cyclophosphamide and etoposide and G-CSF 5 microg/kg/day. None of them had bone marrow involvement at the time of mobilization or a history of extended field irradiation. Previous chemotherapy regimens were divided into two groups: moderately myelotoxic chemotherapy (MMC) and highly myelotoxic chemotherapy (HMC). The adequacy of the PBSC harvest was not associated with age, gender, a past history of bone marrow involvement or disease status. In contrast, the number of MMC cycles (n(MMC)) and the number of HMC cycles (n(HMC)) were both significant (P = 0.009 and P = 0.0004, respectively) and were used to compute a score predictive of a successful PBSC harvest: SCORE = n(MMC) + 4 n(HMC). The estimated successful PBSC collection rate was greater than 80% in patients with a score ranging from 0 to 15 and dropped rapidly to below 20% in patients with a score exceeding 25. This scoring system may help to determine the timing of PBSC mobilization in patients with a score below 15 and suggests that new PBSC mobilization procedures should be investigated in other patients. Bone Marrow Transplantation (2000) 25, 495-499.
对56例化疗敏感的非霍奇金淋巴瘤患者进行研究，以评估影响动员和外周血干细胞（PBSC）采集的因素：所有患者均采用大剂量环磷酰胺、依托泊苷及5μg/kg/天的粒细胞集落刺激因子（G-CSF）进行动员。动员时均无骨髓受累，也无扩大野照射史。既往化疗方案分为两组：中度骨髓毒性化疗（MMC）和高度骨髓毒性化疗（HMC）。PBSC采集的充足程度与年龄、性别、既往骨髓受累史或疾病状态无关。相反，MMC周期数（n(MMC)）和HMC周期数（n(HMC)）均具有显著意义（分别为P = 0.009和P = 0.0004），并用于计算预测PBSC采集成功的评分：评分 = n(MMC) + 4n(HMC)。评分在0至15分的患者中，估计的PBSC成功采集率大于80%，而评分超过25分的患者中，该成功率迅速降至20%以下。该评分系统可能有助于确定评分低于15分患者的PBSC动员时机，并提示应在其他患者中研究新的PBSC动员程序。《骨髓移植》（2000年）第25卷，第495 - 499页 。
