Garjian K V, Pretorius D H, Budorick N E, Cantrell C J, Johnson D D, Nelson T R
Department of Radiology, University of California, San Diego, La Jolla 92093-0610, USA.
Radiology. 2000 Mar;214(3):717-23. doi: 10.1148/radiology.214.3.r00mr23717.
To compare the prenatal ultrasonographic (US) features of skeletal dysplasia by using two-dimensional (2D) and three-dimensional (3D) US to determine whether 3D US can reveal additional diagnostic information.
Seven pregnant women suspected of having skeletal dysplasia were examined by using 2D US and 3D US. Data regarding the thorax, spine, face, limbs, hands, and feet were compared. Multiplanar and volume-rendered US images were evaluated.
The skeletal dysplasias studied included camptomelic dysplasia (n = 2), thanatophoric dysplasia (n = 1), osteogenesis imperfecta (n = 1), arthrogryposis (n = 2), and short-limbed dysplasia (n = 1). Three-dimensional US, by allowing review in a standard anatomic orientation, was better than 2D US in depicting abnormal spatial relationships such as short ribs, splayed digits, and absent bones. Three-dimensional US enabled the acquisition of additional information in two fetuses with facial abnormalities and in two fetuses with scapular aplasia or hypoplasia (one fetus had both facial and scapular anomalies); it enabled a specific diagnosis in one fetus. The archiving capabilities of 3D US allow the review and manipulation of data after the patient has left the clinic.
In three of seven patients, 3D US provided additional information in the evaluation of skeletal dysplasias, as compared with 2D US.
通过二维（2D）和三维（3D）超声比较骨骼发育异常的产前超声（US）特征，以确定3D US是否能揭示更多诊断信息。
对7名疑似骨骼发育异常的孕妇进行2D US和3D US检查。比较胸部、脊柱、面部、四肢、手和脚的数据。评估多平面和容积再现超声图像。
研究的骨骼发育异常包括弯曲侏儒症（n = 2）、致死性侏儒症（n = 1）、成骨不全（n = 1）、关节挛缩症（n = 2）和短肢发育异常（n = 1）。3D US通过允许以标准解剖方位进行观察，在描绘异常空间关系（如短肋骨、手指分开和骨骼缺如）方面优于2D US。3D US能够在2例面部异常胎儿和2例肩胛骨发育不全或发育不良胎儿（1例胎儿同时有面部和肩胛骨异常）中获取更多信息；它能够对1例胎儿做出明确诊断。3D US的存档功能允许在患者离开诊所后对数据进行回顾和处理。
与2D US相比，在7例患者中的3例中，3D US在骨骼发育异常评估中提供了更多信息。
