Celik M, Tuncer S, Emekli U, Kesim S N
Istanbul Cranioplast, Plastic and Craniofacial Surgery Clinic, Turkey.
J Oral Maxillofac Surg. 2000 Mar;58(3):292-5; discussion 296. doi: 10.1016/s0278-2391(00)90056-9.
The purpose of this study was to investigate the cellular quality of prefabricated bone grafts.
Small pieces of iliac bone were placed around the neurovascular bundle on the dorsal aspect of the ear of 11 one-month-old baby rabbits to create a prefabricated vascularized graft. In five animals, the prefabricated bone grafts were harvested for histologic examination 12 months later. In a second group of 6 rabbits, the prefabricated bone grafts, with the neurovascular bundle as a pedicle, were transferred after 30 days to a defect created by removing 1 cm of the midportion of zygoma on the right side of the face. The transferred bone was removed for histologic examination 11 months later.
In both groups, microscopic examination showed the presence of a rich, vascular network and similar histologic characteristics to those of normal iliac bone.
The findings support the concept that prefabricated bone grafts are a potentially useful source for bony reconstruction.
本研究的目的是调查预制骨移植物的细胞质量。
将小块髂骨放置在11只1月龄幼兔耳部背侧的神经血管束周围，以构建预制带血管移植物。在5只动物中，12个月后收获预制骨移植物进行组织学检查。在第二组6只兔子中，以神经血管束为蒂的预制骨移植物在30天后转移至右侧面部颧骨中部去除1 cm所形成的缺损处。11个月后取出转移的骨进行组织学检查。
两组的显微镜检查均显示存在丰富的血管网络，且组织学特征与正常髂骨相似。
这些发现支持预制骨移植物是骨重建潜在有用来源的概念。
