代谢型谷氨酸受体亚型mRNA（mGluR1 - 8）在人小脑中的表达。

Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum.

作者信息

Berthele A, Platzer S, Laurie D J, Weis S, Sommer B, Zieglgänsberger W, Conrad B, Tölle T R

机构信息

Department of Neurology, Technical University, Munich, Germany.

出版信息

Neuroreport. 1999 Dec 16;10(18):3861-7. doi: 10.1097/00001756-199912160-00026.

DOI:10.1097/00001756-199912160-00026

PMID:10716224

Abstract

The expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization. mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells. mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.

摘要

采用原位杂交技术研究了代谢型谷氨酸受体（mGluR）mRNA在人类小脑新皮质中的表达。mGluR1、3和4 mRNA最为丰富且分布广泛，而mGluR2、5和7 mRNA的表达则较为局限。编码mGluR1、3、4和7的mRNA在浦肯野细胞中表达。在颗粒细胞中可检测到mGluR1和4 mRNA，在高尔基细胞中可检测到mGluR1、2、3、4和7 mRNA。在假定的伯格曼胶质细胞中可检测到mGluR5 mRNA，mGluR3 mRNA也在胶质细胞中广泛表达。mGluR8 mRNA在分子层的一部分星状/篮状细胞中表达非常低，而在小脑皮质中未检测到mGluR6 mRNA。