加速寻找人类蛋白质组中的缺失蛋白质。
Accelerating the search for the missing proteins in the human proteome.
机构信息
Department of Biomedical Sciences, Faculty of Medicine &Health Sciences, Macquarie University, New South Wales 2109, Australia.
Department of Chemistry &Biomolecular Sciences, Macquarie University, New South Wales 2109, Australia.
出版信息
Nat Commun. 2017 Jan 24;8:14271. doi: 10.1038/ncomms14271.
The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.
人类蛋白质组计划（HPP）旨在发现人类基因组编码的所有蛋白质的高严谨性数据。目前，人类蛋白质组中约有 18%的蛋白质（缺失蛋白质）没有高严谨性证据（例如质谱法）来确认其存在，而关于许多这些缺失蛋白质的更多信息是可用的。在这里，我们展示了 MissingProteinPedia 作为一个社区资源，以加速这些缺失蛋白质的发现和理解。
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