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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hall D, Froer K L, Loracher C

Clin Sci Mol Med Suppl. 1976 Dec;3:587s-589s. doi: 10.1042/cs051587s.

The chronic administration of minoxidil, 0-024-0-212 mmol (5-40 mg) daily, to fifty-two severely hypertensive patients resulted in an average reduction of mean arterial pressure from 170 to 111 mmHg. 2. Haemodynamic studies in twelve of these patients indicated that the rise in pulmonary arterial pressure in patients without heart failure appears to be a direct result of a disproportionately large increase in cardiac output with respect to a relatively small decrease in pulmonary vascular resistance. Anti-hypertensive treatment of patients with congestive heart failure resulted in a decrease in mean pulmonary arterial pressure.

对52名重度高血压患者每日长期服用米诺地尔，剂量为0.024 - 0.212毫摩尔（5 - 40毫克），平均动脉压从170毫米汞柱降至111毫米汞柱。2. 对其中12名患者的血流动力学研究表明，无心力衰竭患者肺动脉压升高似乎是心输出量不成比例大幅增加以及肺血管阻力相对小幅下降的直接结果。对充血性心力衰竭患者进行抗高血压治疗可使平均肺动脉压降低。

Hall D, Froer K L, Loracher C

Clin Sci Mol Med Suppl. 1976 Dec;3:587s-589s. doi: 10.1042/cs051587s.

The chronic administration of minoxidil, 0-024-0-212 mmol (5-40 mg) daily, to fifty-two severely hypertensive patients resulted in an average reduction of mean arterial pressure from 170 to 111 mmHg. 2. Haemodynamic studies in twelve of these patients indicated that the rise in pulmonary arterial pressure in patients without heart failure appears to be a direct result of a disproportionately large increase in cardiac output with respect to a relatively small decrease in pulmonary vascular resistance. Anti-hypertensive treatment of patients with congestive heart failure resulted in a decrease in mean pulmonary arterial pressure.

对52名重度高血压患者每日长期服用米诺地尔，剂量为0.024 - 0.212毫摩尔（5 - 40毫克），平均动脉压从170毫米汞柱降至111毫米汞柱。2. 对其中12名患者的血流动力学研究表明，无心力衰竭患者肺动脉压升高似乎是心输出量不成比例大幅增加以及肺血管阻力相对小幅下降的直接结果。对充血性心力衰竭患者进行抗高血压治疗可使平均肺动脉压降低。