接受免疫疗法的豚草过敏患者体内，Amb a 1特异性IgE和IgG4的变应原结合能力发生改变。
Altered allergen binding capacities of Amb a 1-specific IgE and IgG4 from ragweed-sensitive patients receiving immunotherapy.
作者信息
Pierson-Mullany L K, Jackola D, Blumenthal M, Rosenberg A
机构信息
Asthma and Allergy Center, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.
出版信息
Ann Allergy Asthma Immunol. 2000 Feb;84(2):241-3. doi: 10.1016/S1081-1206(10)62761-5.
BACKGROUND
The mechanisms for the effectiveness of allergen immunotherapy (IT) are not well understood. The binding potential for immunoglobulins is a function of both antibody concentration and affinity (K(A)).
PURPOSE
The purpose was to perform a cross-sectional preliminary study to investigate any differences in allergen-specific antibody affinity and concentration following ragweed immunotherapy by introducing a new concept of antibody binding capacity ([Ig] X K(A)).
METHODS
The binding capacity of allergen-specific IgE and IgG4 was determined for ragweed-allergic individuals undergoing ragweed immunotherapy and compared with the capacity of ragweed-specific IgE and IgG4 for allergic individuals not receiving immunotherapy.
RESULTS
The mean binding capacity for IgG4 after long-term immunotherapy was 1.6 log units higher (P < .0001) than for individuals not receiving IT. The binding capacity for allergen-specific IgE was 1.2 log units lower following long-term immunotherapy (P < .0001) compared with individuals not receiving ragweed IT.
CONCLUSIONS
We hypothesize that a primary effect of immunotherapy is to increase IgG4 binding capacity and concomitantly decrease IgE binding capacity.
背景
变应原免疫疗法（IT）有效性的机制尚未完全明确。免疫球蛋白的结合潜能是抗体浓度和亲和力（K(A)）的函数。
目的
通过引入抗体结合能力（[Ig]×K(A)）这一新概念，进行一项横断面初步研究，以调查豚草免疫疗法后变应原特异性抗体亲和力和浓度的差异。
方法
测定接受豚草免疫疗法的豚草过敏个体的变应原特异性IgE和IgG4的结合能力，并与未接受免疫疗法的过敏个体的豚草特异性IgE和IgG4的结合能力进行比较。
结果
长期免疫疗法后，IgG4的平均结合能力比未接受IT的个体高1.6对数单位（P <.0001）。与未接受豚草免疫疗法的个体相比，长期免疫疗法后变应原特异性IgE的结合能力低1.2对数单位（P <.0001）。
结论
我们推测免疫疗法的主要作用是增加IgG4结合能力，同时降低IgE结合能力。
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