Guardiola J M, Rodríguez-Pla A, López-Contreras J, Llobet J M, Domingo P, Franco M, Díaz C, Vázquez G
Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
Scand J Rheumatol. 2000;29(1):68-9. doi: 10.1080/030097400750001842.
We herein describe the case of a 77-year-old woman, who presented clinical and histopathological evidence of giant cell arteritis (GCA) involving the temporal artery, together with a Churg-Strauss syndrome (CSS). Our patient presented positive anti-neutrophil cytoplasmic antibodies (ANCA), with cytoplasmic staining pattern (C-ANCA) that was specific against proteinase 3 (PR3), and also a perinuclear pattern (P-ANCA) with specificity against myeloperoxidase (MPO). To our knowledge, the simultaneous presence in the same patient of both types of antibodies has not been previously reported.
我们在此描述了一名77岁女性的病例，该患者呈现出累及颞动脉的巨细胞动脉炎（GCA）以及变应性肉芽肿性血管炎（CSS）的临床和组织病理学证据。我们的患者抗中性粒细胞胞浆抗体（ANCA）呈阳性，具有针对蛋白酶3（PR3）的胞浆染色模式（C-ANCA），以及针对髓过氧化物酶（MPO）的核周模式（P-ANCA）。据我们所知，此前尚未报道过同一患者同时存在这两种抗体的情况。
