Yamanaka K
Department of Neurosurgery, Osaka City University Medical School.
Osaka City Med J. 1999 Jun;45(1):45-59.
To determine the factors related to optimal treatment of brain metastasis from lung cancer by gamma knife radiosurgery, we investigated those influencing survival and local tumor control. We observed 156 patients with 315 such lesions treated by gamma knife radiosurgery (GKS). The factor that most affected survival was whether extracranial disease was controlled at the time of treatment. Patients with a high Karnofsky Performance Score (KPS) tended to survive longer. The local tumor control rate was higher with tumors less than 20 mm in diameter than larger lesions. Tumors treated with a high marginal dose (23 Gy < or =) were better controlled than those treated with a lower marginal dose. Control of extranial lesions, high KPS, small (< 20 mm) lesions, and high marginal dose (23 Gy < or =) were important factors in obtaining good results with GKS for brain metastasis from lung cancer.
为确定与伽玛刀放射外科治疗肺癌脑转移瘤最佳治疗相关的因素，我们研究了那些影响生存和局部肿瘤控制的因素。我们观察了156例接受伽玛刀放射外科（GKS）治疗的315个此类病灶的患者。最影响生存的因素是治疗时颅外疾病是否得到控制。卡诺夫斯基性能评分（KPS）高的患者往往存活时间更长。直径小于20mm的肿瘤局部肿瘤控制率高于较大病灶。采用高边缘剂量（23Gy及以上）治疗的肿瘤比采用低边缘剂量治疗的肿瘤控制得更好。颅外病灶的控制、高KPS、小（<20mm）病灶和高边缘剂量（23Gy及以上）是GKS治疗肺癌脑转移瘤取得良好效果的重要因素。
