Sato A
Kyoto Preventive Medical Center.
Nihon Kokyuki Gakkai Zasshi. 2000 Jan;38(1):3-11.
Human mucosal membrane surfaces have a distinct protective mechanism that is specifically designed to produce secretory IgA. In the airway, bronchus-associated lymphoid tissue (BALT), is known to be an inductive site of secretory IgA. BALT is a lymphoid aggregate located in the submucosal area of bronchioles, and plays a central role in airway mucosal immunity by inducing the accumulation of secretory IgA-producing cells. Although previously it had been unclear whether BALT is present in the human lung, we demonstrated the expression of BALT in patients with diffuse panbronchiolitis, chronic hypersensitivity pneumonitis, and collagen disease-associated lung diseases. BALT was shown to elevate serum IgA levels and in other ways to have an influence on the symptoms and signs in patients with these pathologic conditions. We also demonstrated that continuous inhaled antigenic stimulation as well as the local production of interleukin-4 and other cytokines promote BALT development, which, in turn, may give rise to BALToma, a type of primary pulmonary mucosa-associated lymphoma.
人类黏膜表面有一种独特的保护机制，专门用于产生分泌型IgA。在气道中，支气管相关淋巴组织（BALT）是已知的分泌型IgA诱导部位。BALT是位于细支气管黏膜下区域的淋巴集结，通过诱导分泌型IgA产生细胞的聚集在气道黏膜免疫中发挥核心作用。尽管此前尚不清楚人类肺部是否存在BALT，但我们在弥漫性泛细支气管炎、慢性过敏性肺炎和胶原病相关肺部疾病患者中证实了BALT的表达。结果显示，BALT可提高血清IgA水平，并以其他方式影响这些病理状况患者的症状和体征。我们还证实，持续吸入抗原刺激以及白细胞介素-4和其他细胞因子的局部产生会促进BALT发育，进而可能引发BALToma，一种原发性肺黏膜相关淋巴瘤。
