Kaneko K, Yamanda T, Han'uda M, Miyazawa M, Hanaoka T, Kondo R, Makiuchi A, Amano J
Second Department of Surgery, Shinshuu University School of Medicine.
Nihon Kokyuki Gakkai Zasshi. 2000 Jan;38(1):39-44.
An abnormal shadow was observed on chest X-ray films of a 63-year-old man presenting with cough and sputum. Chest computed tomographic scans disclosed enlargement of the right hilar lymph nodes, but no obvious primary lesion was found in the lung field. Bronchoscopic examination revealed a slightly widened second carina, but no malignant cells were detected by transbronchial aspiration cytology. At surgery, a tumor was found between the truncus superior and the truncus intermedius. The pathologic diagnosis was a metastatic lymph node of poorly differentiated squamous cell carcinoma. Because the tumor severely adhered to the bronchus and pulmonary arteries, we performed a right pneumonectomy with mediastinal node dissection. Pre- and postoperative examinations did not detect the primary lesion, and no recurrence had been observed 76 months after surgery. This was thought to be a very rare case of T0 N1 M0 lung cancer. In general, the prognosis is poor for patients with metastatic carcinoma of unknown primary site. However, patients with T 0 lung cancer, as in this case, might enjoy a better prognosis if complete resection and dissection of metastatic lymph nodes are performed.
一名63岁男性因咳嗽、咳痰就诊,胸部X线片发现异常阴影。胸部计算机断层扫描显示右肺门淋巴结肿大,但肺野未发现明显原发灶。支气管镜检查发现第二隆突稍增宽,但经支气管针吸细胞学检查未发现恶性细胞。手术中发现肿瘤位于上干和中间干之间。病理诊断为低分化鳞状细胞癌转移性淋巴结。由于肿瘤与支气管和肺动脉严重粘连,我们进行了右肺切除术及纵隔淋巴结清扫术。术前和术后检查均未发现原发灶,术后76个月未观察到复发。这被认为是一例非常罕见的T0 N1 M0期肺癌。一般来说,原发部位不明的转移性癌患者预后较差。然而,像本例这样的T0期肺癌患者,如果能完整切除并清扫转移性淋巴结,可能会有较好的预后。