PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation.

作者信息

Sasaki T, Nose H, Hosoya A, Yoshida S, Kawaguchi M, Watanabe T, Usui T, Ohtsuka Y, Shomura T, Takano S, Tatsuta K

机构信息

Pharmaceutical Research Center, Meiji Seika, Ltd., Yokohama, Japan.

出版信息

J Antibiot (Tokyo). 2000 Jan;53(1):38-44. doi: 10.7164/antibiotics.53.38.

The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.