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Gene therapy of malignant gliomas: a phase I study of IL-4-HSV-TK gene-modified autologous tumor to elicit an immune response.

作者信息

Okada H, Pollack I F, Lotze M T, Lunsford L D, Kondziolka D, Lieberman F, Schiff D, Attanucci J, Edington H, Chambers W, Robbins P, Baar J, Kinzler D, Whiteside T, Elder E

机构信息

University of Pittsburgh Cancer Institute, Pennsylvania, USA.

出版信息

Hum Gene Ther. 2000 Mar 1;11(4):637-53. doi: 10.1089/10430340050015824.

DOI:10.1089/10430340050015824
PMID:10724042
Abstract
摘要

相似文献

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Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.单纯疱疹病毒胸苷激酶基因疗法在实验性大鼠BT4C胶质瘤模型中的应用：胸苷激酶阳性胶质瘤细胞百分比对治疗效果、生存时间及组织反应的影响
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In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.通过腺病毒介导的肿瘤细胞转导原位产生假型逆转录病毒后代可增强单纯疱疹病毒胸苷激酶自杀基因疗法在体外和体内的杀伤效果。
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Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.用表达单纯疱疹病毒胸苷激酶的复制型腺病毒载体治疗恶性胶质瘤。
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Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells.恶性脑肿瘤的基因治疗：携带单纯疱疹病毒I型胸苷激酶基因和野生型逆转录病毒的大鼠胶质瘤细胞系可杀死其他肿瘤细胞。
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Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.仅含BH3结构域的细胞死亡激活剂BimS增强胸苷激酶介导的恶性胶质瘤杀伤作用。
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Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.表达胸苷激酶用于治疗恶性胶质瘤的缺陷型单纯疱疹病毒载体
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