Lin W L, Fan W C, Yen J Y, Chen Y Y, Shieh M J
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Int J Radiat Oncol Biol Phys. 2000 Mar 15;46(5):1329-36. doi: 10.1016/s0360-3016(99)00353-3.
The purpose of this paper was to examine the heating patterns and penetration depth when a cylindrical ultrasound transducer is employed for intracavitary hyperthermia treatments.
The present study employs a simulation program based on a simplified power deposition model for infinitely long cylindrical ultrasound transducers. The ultrasound power in the tissue is assumed to be exponentially attenuated according to the penetration depth of the ultrasound beam, and a uniform attenuation for the entire treatment region is also assumed. The distribution of specific absorption rate (SAR) ratio (the ratio of SAR for a point within the tissue to that for a specific point on the cavity surface) is used to determine the heating pattern for a set of given parameters. The parameters considered are the ultrasound attenuation in the tissue, the cavity size, and the transducer eccentricity.
Simulation results show that the ultrasound attenuation in the tissue, the cavity size, and the transducer eccentricity are the most influential parameters for the distribution of SAR ratio. A low frequency transducer located in a large cavity can produce a much better penetration. The cavity size is the major parameter affecting the penetration depth for a small cavity size, such as interstitial hyperthermia. The heating pattern can also be dramatically changed by the transducer eccentricity and radiating sector. In addition, for a finite length of cylindrical transducer, lower SAR ratio appears in the regions near the applicator's edges.
The distribution of SAR ratio indicates the relationship between the treatable region and the parameters if an appropriate threshold of SAR ratio is taken. The findings of the present study comprehend whether or not a tumor is treatable, as well as select the optimal driving frequency, the appropriate cavity size, and the eccentricity of a cylindrical transducer for a specific treatment.
本文旨在研究当使用圆柱形超声换能器进行腔内热疗时的加热模式和穿透深度。
本研究采用基于无限长圆柱形超声换能器简化功率沉积模型的模拟程序。假设组织中的超声功率根据超声束的穿透深度呈指数衰减,并且还假设整个治疗区域的衰减是均匀的。比吸收率(SAR)比(组织内某点的SAR与腔表面特定点的SAR之比)的分布用于确定一组给定参数下的加热模式。所考虑的参数包括组织中的超声衰减、腔的大小和换能器偏心率。
模拟结果表明,组织中的超声衰减、腔的大小和换能器偏心率是影响SAR比分布的最主要参数。位于大腔内的低频换能器可产生更好的穿透效果。对于小腔尺寸(如组织间热疗),腔的大小是影响穿透深度的主要参数。换能器偏心率和辐射扇区也可显著改变加热模式。此外,对于有限长度的圆柱形换能器,在施源器边缘附近区域出现较低的SAR比。
如果采用适当的SAR比阈值,SAR比分布表明了可治疗区域与参数之间的关系。本研究结果有助于理解肿瘤是否可治疗,以及为特定治疗选择最佳驱动频率、合适的腔大小和圆柱形换能器的偏心率。