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普拉德-威利综合征中的多食与自残行为：心理药理学问题

Hyperphagia and self-mutilation in Prader-Willi syndrome: psychopharmacological issues.

作者信息

Yaryura-Tobias J A, Grunes M S, Bayles M E, Neziroglu F

机构信息

Department of Biopsychosocial Research Institute for Biobehavioral Therapy and Research, Great Neck, NY 11021, USA.

出版信息

Eat Weight Disord. 1998 Dec;3(4):163-7. doi: 10.1007/BF03340005.

DOI:10.1007/BF03340005
PMID:10728166
Abstract

This study focused in the treatment of two major Prader-Willi symptoms: hyperphagia and self-injurious behavior (SIB). Four patients participated in a four-year study with monthly follow-ups. Patients lived in a behaviorally structured environment, and were treated with selective serotonin reuptake blockers and phenothiazines. Psychopharmacological intervention improved SIB symptoms, but was ineffective to control appetite satiation.

摘要

本研究聚焦于普拉德-威利综合征的两大主要症状：食欲亢进和自伤行为（SIB）。四名患者参与了一项为期四年的研究，每月进行随访。患者生活在行为结构化的环境中，并接受选择性5-羟色胺再摄取阻滞剂和吩噻嗪类药物治疗。心理药理学干预改善了自伤行为症状，但对控制饱腹感无效。

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