Xiao B G, Xu L Y, Yang J S, Huang Y M, Link H
Units of Experimental Neurology and Neuroimmunology, Division of Neurology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Stockholm, Sweden.
Neurosci Lett. 2000 Mar 31;283(1):53-6. doi: 10.1016/s0304-3940(00)00914-9.
In the present study, we observed an alternative pathway in which nitric oxide (NO) production by rat astrocytes requires specific antigen and cell-cell contact. NO production by astrocytes was significantly inhibited by antibodies against CD40L, B7-1 or B7-2. Astrocyte-derived NO inhibited T cell proliferation and induced T cell apoptosis. In contrast, augmented astrocyte proliferation was correlated to the levels of NO production by astrocytes, implicating a role of NO in regulating local immune responses in the central nervous system. These results suggest that T cell-astrocyte interactions may regulate local immune responses via the NO pathway and influence the fate of infiltrating T cells.
在本研究中，我们观察到一种替代途径，即大鼠星形胶质细胞产生一氧化氮（NO）需要特定抗原和细胞间接触。抗CD40L、B7-1或B7-2抗体可显著抑制星形胶质细胞产生NO。星形胶质细胞衍生的NO抑制T细胞增殖并诱导T细胞凋亡。相反，星形胶质细胞增殖增强与星形胶质细胞产生NO的水平相关，这表明NO在调节中枢神经系统局部免疫反应中起作用。这些结果表明，T细胞与星形胶质细胞的相互作用可能通过NO途径调节局部免疫反应，并影响浸润T细胞的命运。
