Mizutani K, Oda Y, Terai T, Yukioka H, Asada A
Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Japan.
Osaka City Med J. 1999 Dec;45(2):129-38.
This study was undertaken to determine whether preoperative epidural morphine using double-catheter technique would improve postoperative analgesia in patients undergoing esophagectomy with or without continuous intraoperative epidural lidocaine in a randomized double-blind and controlled manner. Thirty patients undergoing esophagectomy for esophageal cancer received preoperative epidural morphine 2 mg at T 6-7 and 2 mg at L 3-4 through the catheters, respectively. Thereafter, continuous thoracic epidural infusion of either 1% lidocaine (lidocaine group, n = 15) or normal saline solution (control group, n = 15) at 6 ml/h was initiated. After surgery, mean verbal rating scale of pain (0 to 10) at rest was maintained below 4 and pain on deep breathing was maintained mild in all patients in both groups. There was no significant difference in these values between the groups. In conclusion, preoperative epidural morphine using double-catheter technique provided adequate analgesia following esophagectomy. The addition of intraoperative continuous epidural lidocaine did not improve analgesia.
本研究旨在以随机双盲对照的方式,确定采用双导管技术术前硬膜外给予吗啡,对于行食管切除术的患者,无论术中是否持续给予硬膜外利多卡因,术后镇痛效果是否会得到改善。30例因食管癌接受食管切除术的患者,分别通过导管在T6-7和L3-4水平给予术前硬膜外吗啡2mg。此后,持续胸段硬膜外输注1%利多卡因(利多卡因组,n = 15)或生理盐水(对照组,n = 15),速度为6ml/h。术后,两组所有患者静息时的平均语言疼痛评分(0至10分)均维持在4分以下,深呼吸时疼痛均较轻。两组间这些值无显著差异。总之,采用双导管技术术前硬膜外给予吗啡,在食管切除术后可提供充分的镇痛效果。术中持续硬膜外给予利多卡因并未改善镇痛效果。