Whittaker J W
Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, Portland 97291-1000, USA.
Essays Biochem. 1999;34:155-72. doi: 10.1042/bse0340155.
The copper oxidases are a remarkable family of metalloenzymes that have evolved specialized mechanisms to accomplish the controlled reduction of dioxygen, delivering the equivalent of H2 from organic substrates to O2 to form hydrogen peroxide, a ubiquitous oxygen metabolite that is involved in a wide range of biological interactions. These enzymes display their virtuosity in dioxygen chemistry by harnessing the oxidizing power of that molecule not only during catalytic turnover, but also in transforming themselves in the biogenesis of their catalytic redox cofactor.
铜氧化酶是一类卓越的金属酶家族，它们进化出了专门的机制来实现对双氧的可控还原，将有机底物中的相当于H2的物质传递给O2以形成过氧化氢，过氧化氢是一种普遍存在的氧代谢产物，参与广泛的生物相互作用。这些酶不仅在催化周转过程中利用双氧分子的氧化能力，而且在其催化氧化还原辅因子的生物合成过程中自我转化，从而展现出它们在双氧化学方面的精湛技艺。
