脂蛋白(a)的促动脉粥样硬化特性可能通过形成含有肺炎衣原体特异性IgG抗体的循环免疫复合物而增强。

The proatherogenic properties of lipoprotein(a) may be enhanced through the formation of circulating immune complexes containing Chlamydia pneumoniae-specific IgG antibodies.

作者信息

Glader C A, Boman J, Saikku P, Stenlund H, Weinehall L, Hallmanns G, Dahlén G H

机构信息

Departments of Clinical Chemistry, Umeå University, Sweden.

出版信息

Eur Heart J. 2000 Apr;21(8):639-46. doi: 10.1053/euhj.1999.1755.

DOI:10.1053/euhj.1999.1755

PMID:10731401

Abstract

AIMS

To investigate a possible relationship between the atherogenic properties of lipoprotein(a) (Lp(a)) and Chlamydia pneumoniae infections.

METHODS AND RESULTS

The study population was nested within the Västerbotten Intervention Program or the WHO MONICA project. In this incident case-control study, 78 patients who had suffered acute myocardial infarction and 156 matched controls were included. The contents of circulating immune complexes were analysed for C. pneumoniae IgG antibodies and Lp(a). A significantly larger proportion of cases than controls had >/=13 mg. l(-1)Lp(a) and a C. pneumoniae specific IgG antibody titre >/=1/2 in circulating immune complexes (odds ratio=3.8).

CONCLUSION

The proatherogenic effects of Lp(a) may be enhanced and/or partly mediated through the formation of circulating immune complexes containing C. pneumoniae -specific IgG antibodies. The connection between chronic C. pneumoniae infections and atherosclerosis may, at least in part, be explained by an interaction with Lp(a) through the formation of circulating immune complexes.

摘要

目的

研究脂蛋白(a)（Lp(a)）的致动脉粥样硬化特性与肺炎衣原体感染之间的可能关系。

方法与结果

研究人群来自于韦斯特博滕干预计划或世界卫生组织心血管疾病监测趋势和决定因素（MONICA）项目。在这项病例对照研究中，纳入了78例急性心肌梗死患者和156例匹配的对照。分析循环免疫复合物中肺炎衣原体IgG抗体和Lp(a)的含量。病例组中Lp(a)≥13mg·l⁻¹且循环免疫复合物中肺炎衣原体特异性IgG抗体滴度≥1/2的比例显著高于对照组（比值比=3.8）。