Ando K, Yaguchi M, Okabe S, Miyazawa K, Ohyashiki K
First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku.
Intern Med. 2000 Feb;39(2):170-5. doi: 10.2169/internalmedicine.39.170.
A 72-year-old man was admitted to our hospital because of lumbago and numbness of legs. Tumor invasion at the fourth lumbar vertebra was revealed. Immunohistochemistry using specific antibodies against each heavy and light chain of immunoglobulin revealed that the myeloma cells in bone marrow were all IgA-lambda type whereas they were all positive for IgG-kappa type in a tumor of the fourth lumbar vertebra. These data indicate that the patient had IgG-kappa/IgA-lambda biclonal myeloma. Different phenotypes of M-proteins and distinct proliferating sites for two clones suggest that they may have resulted from two independent transforming events.
一名72岁男性因腰痛和腿部麻木入院。检查发现第四腰椎有肿瘤侵犯。使用针对免疫球蛋白各重链和轻链的特异性抗体进行免疫组化检测显示，骨髓中的骨髓瘤细胞均为IgA-λ型，而第四腰椎肿瘤中的骨髓瘤细胞均为IgG-κ型阳性。这些数据表明该患者患有IgG-κ/IgA-λ双克隆骨髓瘤。M蛋白的不同表型以及两个克隆不同的增殖部位提示它们可能源于两个独立的转化事件。
