72例多发性骨髓瘤患者单克隆蛋白分析
[Analysis of monoclonal protein in 72 cases of multiple myeloma].
作者信息
Yang J J, Zhang G S, Chen X R
机构信息
Department of Hematology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 2001 Apr 28;26(2):152-4.
Serum and urinary monoclonal proteins (M protein) were measured in 72 cases of multiple myeloma (MM) using rate nephelometry. In IgG and IgA types of MM, the level of immunoglobulin (Ig) corresponding to the malignant isotype was significantly higher and that of Ig uncorresponding to the malignant isotype lower than the normal level. The light chain corresponding to the malignant isotype in serum was increased and the light chain uncorresponding to that in serum was decreased either kappa-IgG, IgA types or lambda-IgG, IgA types. Either kappa-LC or lambda-LC type of MM, the serum light chain corresponding to the malignant isotype was in the normal range and uncorresponding to that was decreased, and the corresponding light chain in urine was significantly elevated. Kappa/lambda ratio in serum and urine was all significantly abnormal in IgG, IgA, and LC types of MM. Our data suggest that any quota among kappa light chain > 20 g.L-1 or < 5 g.L-1, lambda light chain > 10 g.L-1 or < 2 g.L-1 in serum and kappa/lambda ratio > 5 or < 0.75 in serum and urine has an important value for diagnosing MM.
采用速率散射比浊法对72例多发性骨髓瘤（MM）患者的血清和尿液单克隆蛋白（M蛋白）进行检测。在IgG型和IgA型MM中，与恶性同种型对应的免疫球蛋白（Ig）水平显著高于正常水平，而与恶性同种型不对应的Ig水平低于正常水平。血清中与恶性同种型对应的轻链增加，而血清中不对应的轻链无论是κ-IgG、IgA型还是λ-IgG、IgA型均减少。无论是κ-LC型还是λ-LC型MM，血清中与恶性同种型对应的轻链在正常范围内，不对应的轻链减少，而尿液中相应的轻链显著升高。IgG型、IgA型和轻链型MM患者血清和尿液中的κ/λ比值均显著异常。我们的数据表明，血清中κ轻链>20 g.L-1或<5 g.L-1、λ轻链>10 g.L-1或<2 g.L-1，以及血清和尿液中κ/λ比值>5或<0.75中的任何一项指标对MM的诊断具有重要价值。
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