Işcan M, Eke B C, Aygörmez S, Coban T, Bülbül D
Department of Toxicology, Faculty of Pharmacy, Ankara University, Turkey.
Neoplasma. 1999;46(6):363-7.
7-Ethoxylesorufin O-deethylase (EROD) (mainly catalyzed by cytochrome P450 (CYP) 1A1 and used as a marker for CYP 1A1) activity was measured in the breast tumor and surrounding tumor free (normal) tissues of 37 female breast cancer patients with infiltrating ductal carcinoma. About 11% of the tumor and normal breast tissue samples lacked the enzyme activity. Large interindividual variations in the activities of EROD were found in both tumor and normal tissues ranging from 0 to 283 and 0 to 801 fmol/mg/min, respectively. However, no significant difference was noted between the mean EROD activities of tumor and normal breast tissues. This tendency did not change with the stage and grade of the malignancy and menopausal status. No significant correlation was observed between the EROD activity and stage or grade of malignancy (p > 0.05). Thus, it appears that EROD activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
在37例浸润性导管癌女性乳腺癌患者的乳腺肿瘤及周围无肿瘤（正常）组织中，检测了7-乙氧基试卤灵O-脱乙基酶（EROD）（主要由细胞色素P450（CYP）1A1催化，用作CYP 1A1的标志物）活性。约11%的肿瘤和正常乳腺组织样本缺乏该酶活性。在肿瘤组织和正常组织中均发现EROD活性存在较大个体差异，分别为0至283和0至801 fmol/mg/分钟。然而，肿瘤组织和正常乳腺组织的平均EROD活性之间未发现显著差异。这种趋势不会随着恶性肿瘤的分期、分级和绝经状态而改变。EROD活性与恶性肿瘤的分期或分级之间未观察到显著相关性（p>0.05）。因此，EROD活性似乎无法反映乳腺癌组织的总体恶性潜能。
