Jezernik S, Wen J G, Rijkhoff N J, Djurhuus J C, Sinkjaer T
Center for Sensory-Motor Interaction, Aalborg University, Denmark.
J Urol. 2000 Apr;163(4):1309-14.
Electrical stimulation of appropriate lower urinary tract (LUT) nerves may be used in bladder dysfunction to achieve continence and abolish hyper-reflexic detrusor contractions. It can also be used for consequent emptying of the bladder. To control the time course of the described functional phases, knowledge of bladder sensory information is needed. We investigated if the latter could be extracted from the LUT nerve activity.
In acute experiments using 10 pigs, tripolar cuff electrodes were placed unilaterally around the pelvic nerve and the S3 and S2 roots. The cuff electrode signals, filling rate and the bladder and rectal pressures were recorded during slow and fast bladder fillings/emptyings.
Two pigs were excluded from the analysis because of no observed changes in the nerve signals in one animal, and because of electrical noise problems in the other animal. Fast bladder pressure increases resulted in a sudden pelvic nerve signal rise in 6 out of 7 pigs (3 out of 6 for the S3 nerve signal). Slow bladder pressure increase was reflected in the recorded nerve activity only in 3 out of 8 and in 3 out of 7 pigs for the pelvic and S3 cuff signals respectively. In 2 animals small spontaneous bladder contractions were clearly reflected in the pelvic nerve signal (contractions were observed only in 3 pigs). Except in one pig, there were no slow/fast bladder filling responses recorded in the S2 roots. It is shown that the recorded responses were afferent.
Cuff electrodes can be used to record bladder afferent information from the pelvic nerve and the sacral root S3 in pig. Pelvic nerve recordings were more selective than the sacral root recordings. Nerve activity increases were more distinct and repeatable during rapid bladder pressure changes and small spontaneous bladder contractions than during slow bladder fillings.
对合适的下尿路（LUT）神经进行电刺激可用于治疗膀胱功能障碍，以实现控尿并消除逼尿肌反射亢进性收缩。它还可用于随后的膀胱排空。为了控制上述功能阶段的时间进程，需要了解膀胱感觉信息。我们研究了是否可以从LUT神经活动中提取后者。
在对10头猪进行的急性实验中，将三极袖带电极单侧放置在盆神经以及S3和S2神经根周围。在膀胱缓慢和快速充盈/排空过程中记录袖带电极信号、充盈率以及膀胱和直肠压力。
由于一只动物的神经信号未观察到变化，另一只动物存在电噪声问题，因此将两只猪排除在分析之外。7头猪中有6头（S3神经信号6头中有3头）在膀胱压力快速升高时盆神经信号突然上升。膀胱压力缓慢升高仅分别在8头猪中的3头以及7头猪中的3头中反映在记录的盆神经和S3袖带信号的神经活动中。在2只动物中，小的自发性膀胱收缩在盆神经信号中得到明显反映（仅在3头猪中观察到收缩）。除了一头猪外，在S2神经根中未记录到缓慢/快速膀胱充盈反应。结果表明记录的反应是传入性的。
袖带电极可用于记录猪盆神经和骶神经根S3的膀胱传入信息。盆神经记录比骶神经根记录更具选择性。与膀胱缓慢充盈相比，在膀胱压力快速变化和小的自发性膀胱收缩期间神经活动增加更明显且可重复。
