“搭桥血管成形术血运重建研究（BARI）”随机试验及登记研究的设计、患者群体和结果。

The design, patient population and outcomes from the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial and registries.

作者信息

Brooks M M, Detre K M

机构信息

The Epidemiology Data Center, University of Pittsburgh, PA 15261, USA.

出版信息

Semin Interv Cardiol. 1999 Dec;4(4):191-9. doi: 10.1006/siic.1999.0100.

DOI:10.1006/siic.1999.0100

PMID:10738352

Abstract

The Bypass Angioplasty Revascularization Investigation (BARI) was designed to compare CAGB and PTCA for patients with symptomatic multivessel coronary artery disease. The randomized trial reported significant differences in 7-year survival favouring CABG. However, for the 353 patients with treated diabetes mellitus, an overwhelming benefit associated with CABG was seen (mortality: 23.6% CABG vs 44. 3% PTCA, p=0.0011), whilst no treatment difference was observed for the 1476 non-diabetic patients (13.6% CABG vs 13.2% PTCA, p=0.72). Patients assigned to PTCA experienced fewer in-hospital Q-wave MIs, but these patients received more revascularization procedures and more often had angina during follow-up.

摘要

旁路血管成形术血运重建研究（BARI）旨在比较冠状动脉搭桥术（CABG）和经皮冠状动脉腔内血管成形术（PTCA）在有症状的多支冠状动脉疾病患者中的疗效。该随机试验报告称，在7年生存率方面，冠状动脉搭桥术具有显著优势。然而，在353例接受治疗的糖尿病患者中，冠状动脉搭桥术显示出压倒性的益处（死亡率：冠状动脉搭桥术为23.6%，经皮冠状动脉腔内血管成形术为44.3%，p=0.0011），而在1476例非糖尿病患者中未观察到治疗差异（冠状动脉搭桥术为13.6%，经皮冠状动脉腔内血管成形术为13.2%，p=0.72）。接受经皮冠状动脉腔内血管成形术的患者住院期间Q波心肌梗死发生率较低，但这些患者接受了更多的血运重建手术，且在随访期间更常出现心绞痛。