Rebischung C, Pautier P, Morice P, Lhomme C, Duvillard P
Department of Medicine, Department of Surgery, Department of Pathology, Institut Gustave Roussy, 39 rue Camille-Desmoulin, Villejuif, 94805, France.
Gynecol Oncol. 2000 Apr;77(1):203-5. doi: 10.1006/gyno.1999.5653.
Elevated levels of alpha-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an alpha-fetoprotein-producing malignant mixed Müllerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component.
甲胎蛋白（AFP）是一种胎儿血清蛋白，其水平升高通常预示着肝癌或生殖细胞肿瘤的发生，包括内胚窦瘤。我们报告了一例52岁女性，患有卵巢产生甲胎蛋白的恶性混合性苗勒管肿瘤（MMMT）。诊断时血清AFP为5348 ng/ml。免疫组化证实，这种双相肿瘤的癌性成分是AFP产生的部位。经过三个周期的联合化疗，患者实现了完全缓解。血清AFP与治疗反应密切相关。这是首例关于无卵黄囊成分的卵巢MMMT产生AFP的报告。
