Tissier F, De Roquancourt A, Astier B, Espie M, Clot P, Marty M, Janin A
Service d'Anatomie Pathologique, Hôpital Cochin, Paris, France.
Ann Pathol. 2000 Mar;20(2):110-4.
We report six cases of carcinomas arising within fibroadenomas. Fibroadenoma is a benign neoplasm occurring in young women. Its association with carcinomas is unfrequent and particularly reported in older women. Few data are available on the histologic features of fibroadenomas harboring malignant lesions. In this study, most cases of fibroadenomas showed cysts, sclerosing adenosis, epithelial calcifications or papillary apocrine changes. These fibroadenomas are classified as complex and are a long-term risk factor for breast cancer. The complex fibroadenoma may be specific of fibroadenoma associated with carcinoma.
我们报告了6例发生于纤维腺瘤内的癌。纤维腺瘤是发生于年轻女性的一种良性肿瘤。它与癌的关联并不常见,尤其多见于老年女性。关于伴有恶性病变的纤维腺瘤的组织学特征,目前可获得的数据较少。在本研究中,大多数纤维腺瘤病例表现为囊肿、硬化性腺病、上皮钙化或乳头状大汗腺改变。这些纤维腺瘤被归类为复杂性纤维腺瘤,是乳腺癌的一个长期危险因素。复杂性纤维腺瘤可能是与癌相关的纤维腺瘤所特有的。