Vraa S, Keller J O, Nielsen O S, Sneppen O, Jurik A G, Jensen O M
Sarkomcentret i Arhus, Arhus Universitetshospital.
Ugeskr Laeger. 2000 Feb 14;162(7):931-5.
In the present study, the outcome, patterns of local recurrence and survival, as well as prognostic factors, were evaluated in patients surgically treated for soft tissue sarcomas. Between January 1979 and July 1993, 316 consecutive patients were referred to the Sarcoma Centre in Aarhus with localised malignant soft tissue sarcoma of the extremities or trunk. There were 161 men (51%) and 155 women (49%), the median age was 56 years (1-94). Histologically 52 patients (16%) had a grade I, 60 patients (19%) a grade 2 and 204 patients (65%) a grade 3A or 3B tumour. The five-year local recurrence rate was 18% and the five-year survival rate was 75%. Multivariate analysis indicated the following variables as independent unfavourable factors for local recurrence: extracompartmental location, histological high-grade (i.e. histologically highly malignant) local excision, no adjuvant radiotherapy and intralesional/marginal excision. Independent unfavourable factors for survival were advanced age, extracompartmental location, histological high-grade, lower extremity location and large tumour size. Based on these variables, a prognostic model was made.
在本研究中，对接受软组织肉瘤手术治疗的患者的结局、局部复发和生存模式以及预后因素进行了评估。1979年1月至1993年7月期间，316例连续患者因四肢或躯干局限性恶性软组织肉瘤被转诊至奥胡斯肉瘤中心。其中男性161例（51%），女性155例（49%），中位年龄为56岁（1 - 94岁）。组织学上，52例患者（16%）为I级肿瘤，60例患者（19%）为2级肿瘤，204例患者（65%）为3A或3B级肿瘤。五年局部复发率为18%，五年生存率为75%。多变量分析表明，以下变量是局部复发的独立不利因素：肿瘤位于筋膜外、组织学高级别（即组织学上高度恶性）、局部切除、未进行辅助放疗以及病灶内/边缘切除。生存的独立不利因素为高龄、肿瘤位于筋膜外、组织学高级别、下肢肿瘤以及肿瘤体积大。基于这些变量，建立了一个预后模型。
